Dortmund are second in the Bundesliga, but level on 40 points with both leaders Bayern Munich and third-placed Schalke and Borussia have the chance to steal a march on their rivals.
A win at Nuremberg would see Dortmund go top and put the pressure on Bayern to win at Hamburg, whose coach Thorsten Fink has said his team will have to 'scratch, bite and fight' if they want to beat Munich.
A cold front is sweeping across northern Europe and the temperature is expected to be between minus 10 and 12 degrees in the Nuremberg stadium come kick-off on Friday night.
The German Football Federation (DFB) has said postponed games are not expected as all Bundesliga clubs have under-soil heating.
The thermometer dipped to -13 in Dortmund's 1-0 win over Freiburg in December 2009, but Borussia's brand of attacking football is running hot and has caught the eye recently.
Japan winger Shinji Kagawa scored twice in their 3-1 win over Hoffenheim last weekend, a week after Dortmund hammered Hamburg 5-1 in the Hanseatic city to put the pressure on Bayern.
"Dortmund are the yardstick at the moment, they have already put together two spectacular performances, for me they will be the champions this summer," said Nuremberg coach Dieter Hecking.
On Saturday night, Bayern have their work cut out at Hamburg, who showed plenty of courage to come away from Hertha Berlin with a 2-1 victory last Saturday, having been hammered by Dortmund the week before.
"We will not raise the white flag or throw in the towel," said Fink, whose team have lost just once in 10 games since he took charge.
Fink, 44 and who won four titles as a player at Bayern, took over as Hamburg coach in October after an eyecatching spell with Swiss side FC Basel, but says there will be no love lost against his old club.
"We battle for our points and we will keep our foot on the gas, that is the only thing I want to see from my team. We need to scratch, bite and fight.
Munich defender Jerome Boateng, who used to play for Hamburg, says his team will be on their guard at Hamburg with the hosts set to offer the Bavarians a frosty reception.
"I know from my time at Hamburg, it is not an easy game for Bayern, they are highly motivated," said Boateng.
"Hamburg tried to play (against Dortmund), I do not think they will try that with us," said Boateng.
"They will be trying not to make mistakes and to counter, but we want to win quite clearly."
Having come from behind to beat Cologne 4-1 on Saturday, Schalke take on Mainz on Saturday and are hoping to have striker Raul back and captain Bendikt Hoewedes in the starting line-up.
Raul sat out the win at Cologne with a calf strain, while defender Hoewedes broke his cheekbone in three places in a collision with a team-mate in the win over Stuttgart a fortnight ago and is expected to play with a mask.
Fourth-placed Moenchengladbach, who are just a point behind Bayern, Dortmund and Schalke, need to win at Wolfsburg on Saturday to stay in touch with the leaders, but looked impressive in their 3-0 at Stuttgart last Sunday.
Fixtures
Friday:
Nuremberg v Borussia Dortmund
Saturday:
Hertha Berlin v Hanover 96, Schalke 04 v Mainz 05, Bayer Leverkusen v VfB Stuttgart, VfL Wolfsburg v Borussia M'gladbach, Hoffenheim v Augsburg, Hamburg v Bayern Munich
Sunday:
Freiburg v Werder Bremen, Kaiserslautern v Cologne
What the stars mean:
★ Poor ★ ★ Promising ★★★ Good ★★★★ Very good ★★★★★ Exceptional