Leander Paes (L) of India and Radek Stepanek (R) of the Czech Republic talk during their men's doubles final in New York. (AFP/Elsa)
India's Paes, 40, and 34-year-old Czech Stepanek, the fourth seeds, defeated Alexander Peya of Austria and Brazil's Bruno Soares, the second seeds, 6-1, 6-3.
It was their second major title as a pair, the Asian star's third in New York and eighth in total.
But Stepanek admitted victory had not been drama free.
Paes almost suffered a broken nose when a ball hit him in the face during their second round against Daniel Brands and Philipp Oswald, before the duo got caught up in another medical drama.
"A security girl was standing by the court. She passed out. I just ran there to see what happened and ran for water, towel, ice, everything, then I checked-up on Lee again, to see if he's doing fine, then back to this girl," he said.
"We took quite a long time to get help. Her heart had stopped twice during those five or 10 minutes. They brought her back. I know she was fine. It was great news."
Paes and Stepanek won the 2012 Australian Open title and had ended Bob and Mike Bryan's hopes of completing a calendar year Grand Slam with victory in the semi-finals on Thursday.
Paes had won the US Open title with Martin Damm in 2006 and Lukas Dlouhy in 2009 and now has eight men's doubles trophies at the majors as well as six mixed doubles crowns.
"My best advice, if you want to succeed at doubles, is to find a partner from the Czech Republic," said Paes, who has now won titles in three different decades.
He also dedicated the win to his coach, Rick Leach, who has been shuttling between New York and California to care for his sick father.
"He's a real champion. Thanks for supporting us," Paes added.
"Radek helped me to get to be the oldest man to ever win a Grand Slam in the Open era. I thank him for that, and we are definitely not done. I'm going after 41 now, 42, and then 43."
Stepanek praised Paes for standing by him when he was out of action for three months earlier this year after undergoing spinal surgery.
"I didn't know how long the recovery would take. It was a real tough time and didn't know when I would be playing again. But Leander stayed with me. He could have gone with another partner," said the Czech.
"That's what makes our friendship so special."
Victory on Sunday was eased when Peya picked up a back injury and needed a medical time-out during the fourth game of the second set.
He continued for the rest of the final but only at walking pace.
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