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The heavyweight player shed 1.27 per cent to HK$81.80 ($10.53) by midday as the broader Hang Seng Index fell 0.83 per cent.
The bank, which survived the 2008 global financial crisis without state aid unlike many of its rivals, said Wednesday it would seek to save $2.5-3.5 billion in costs within two years.
Its new chief executive Stuart Gulliver said the savings would be ploughed back into fast-growing markets around the world, especially in Asia.
The banking titan also said it will conduct a separate assessment of its US branch network and cards business, which could be sold at a "sensible" price. Other cash-saving measures include a streamlining of IT operations.
HSBC reported a mixed first-quarter earnings on Monday.
It said net profit surged 58 per cent to $4.15 billion the the January-March period on lower taxes and fewer bad debts while pre-tax gains were hit by rising staff costs and money set aside to compensate British customers who were mis-sold credit insurance.
HSBC was founded in Hong Kong and Shanghai in 1865 and the bank regards Asia as its most important region.
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